2017

Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq

To determine the effect of aspirin, curcumin and their combination in azoxymethane/dextran ...

2016

Effects of curcumin on Helicobacter pylori infection

To compare the antibacterial effects of five different formulations of curcumin....

Photopreventive effect and mechanism of azd4547 and Curcumin C3 Complex® on UVB-induced epidermal hyperplasia

To investigate the efficacy of Curcumin C3 Complex® for protection against acute UVB induced hyper proliferation by FGFR/mTOR signaling pathway...

2013

Curcumin inhibits UV radiation-induced skin cancer in SKH-1 mice

To study if curcumin has inhibitory effects on formation of skin cancers arising de novo from chronic exposure to UV radiation using a similar in vivo murine model...

2012

Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth

To examine the effects of Curcumin on the activation and differentiation of MDSCs, their interaction with human cancer cells, and related tumor growth...

Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer

To study the effect of bioavailable curcuminoid complex on lung carcinogenesis, primarily by inhibiting Stat3 activation and to inform...

Topical curcumin-based cream is equivalent to dietary curcumin in a skin cancer model.

To determine if topical Curcumin was as efficacious as oral curcumin in a SCC skin xenograft model, to elucidate the pathways down-regulated by Curcumin...

2011

Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo

To determine whether curcumin has growth-inhibitory effects on cutaneous SCCa using an in vivo murine model....

A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease

To explore the effect of a curcuminoid mixture and its individual components on inflammatory and apoptotic genes expression in AD using an Aβ+ibotenic acid-infused rat model....

Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices

To study the effect of Curcuminoids on Aβ-peptide-induced long-term potentiation (LTP) impairment, in an attempt to provide cellular basis of memory enhancement in AD....

2010

Curcumin inhibits carcinogen and nicotine-induced mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma

To examine the effects of Curcumin on HNSCC growth in a variety of HNSCC cell lines, xenograft model and in a carcinogen-induced survival study...

Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation

To explore potential molecular mechanisms of Curcumin in multidrug-resistant protein 2 knockout (Mdr2-/-) mice, a genetic model of progressive cholangiopathy with biliary fibrosis...

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease.

To investigate the effects of curcuminoid mixture and individual constituents on spatial learning and memory in an amyloid-beta (Aβ) peptide-infused rat model of AD ...

2009

Attenuation of proteolysis and muscle wasting by Curcumin C3 Complex® in MAC16 colon tumour-bearing mice

To understand the effect of curcumin C3 Complex® (Curcumin C3) on attenuation of muscle proteolysis using in vitro and in vivo models...

Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease.

To evaluate whether curcuminoids possess acetylcholinesterase (AChE) inhibitory and memory enhancing activities...

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model

To determine whether Curcumin can modulate the effects of capecitabine against CRC, in an orthotopic nude mouse model...

Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model

To investigate whether Curcumin can overcome chemoresistance and enhance the activity of thalidomide and bortezomib...

2008

Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-ĸB-regulated gene products

To investigate the effect of Curcumin on the growth of colorectal cancer xenografts in nude mice exposed to radiation...

Dietary Curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity

To investigate whether Curcumin could attenuate the pro-inflammatory, endocrine and metabolic consequences of obesity in genetically obese Lep^ob/obmice....

2005

Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice.

To determine whether Curcumin inhibits paclitaxel-induced NF-ĸB activation and NF-ĸB–regulated gene products and prevent breast cancer metastasis to the lung...

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.

To investigate whether efficacy of Curcumin in AD models could be explained by effects on Aβ aggregation...